甲状腺素对HepG2细胞氧化损伤的保护作用

Protective Effect of Thyroid Hormone on Oxidative Damage in HepG2 Cells

DOI：10.3969/j.issn.1673-1689.2014.09.007

中文关键词: 甲状腺激素 HepG2细胞 过氧化氢 抗氧化

英文关键词: thyroid hormone（T3）, HepG2, H2O2, apoptosis

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中文摘要:

研究甲状腺激素（T3）对人肝癌细胞（HepG2）氧化损伤的保护作用。体外建立HepG2细胞H2O2氧化损伤模型，添加不同浓度T3进行保护，测定T3对细胞ROS、存活率、抗氧化酶及相关基因的影响。10-9、10-7、10-5 mol/L的T3预处理24 h可分别有效降低50、100、200 μmol/L H2O2处理细胞的ROS水平，提高细胞存活率（p

英文摘要:

To investigate the protect effects of thyroid hormone(T3) on HepG2 with oxidative damage. Establishing an oxidative stress model of HepG2 cells cultured in vitro, adding different concentrations of T3 for protection, determining the differentiation of cellular ROS, survival, antioxidant enzymes and related genes. Pretreatment of 10-9, 10-7, 10-5 mol/L T3 for 24 h, the level of ROS significantly reduced and the survival rate of cells was significantly increased(p

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