紫甘薯多糖对辐射的防护作用

Study on the Radioprotection by Purple Sweet Potato Polysaccharide in Vivo

DOI：

中文关键词: 紫甘薯 多糖 137Csγ-射线 抗辐射

英文关键词: purple sweet potato polysaccharide 137Cs γ-rays radioprotection

基金项目:国家“十一五”科技支撑计划项目(2006BAD27B06)

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中文摘要:

探究在137Csγ-射线单次辐射下,紫甘薯多糖对小鼠辐射损伤的保护作用及机制。小鼠被分为5组:对照组、辐射模型组、多糖高、中、低剂量组。小鼠在照射前1 d,照后3、14 d检测外周血白细胞总数3次。在照后14 d,处死小鼠,观察多糖对小鼠的胸腺系数和脾脏系数、胸骨骨髓细胞的微核率、脾结节数的影响,测定小鼠血清中的SOD、CAT活性和MDA含量,肝、肾组织中的SOD、GSH-PX、CAT活性和MDA含量各项抗氧化指标。结果实验表明,在4 Gy137Csγ-射线辐射情况下,与辐射模型组进行比较,紫甘薯多糖对小鼠外周血白细胞总数、胸腺系数、脾脏系数、胸骨骨髓细胞的微核率、脾结节数都有显著提高;显著提高小鼠血清中SOD活性,提高脾、肾组织中SOD、GSH-PX和CAT活性,降低小鼠血清、脾、肾组织中MDA含量。结论紫甘薯多糖在体内对137Cs-γ射线辐射损伤小鼠具有保护作用。

英文摘要:

In this study we investigated the radioprotective activity of polysaccharide from purple sweet potato in mice irradiated by a 137Cs gamma(γ) ray(4.0 Gy,at a dose of 2.299×102C/kg·min-1).Mice were randomly divided into the control group and four experimental groups which were given polysaccharide from purple sweet potato(model group,low group,middle group,high group) for 30 days.The four experimental groups of mice were then exposed to 137Cs γ-rays and were given polysaccharide from purple sweet potato for a further 14 days.The number of white blood cells,the number of micronuclei in polychromatophilic erythrocytes of bone marrow in mice and the number of spleen colony-forming cells(CFU-S) were carefully determined.The activity of superoxide dismutase,glutathione peroxidase,catalase,malondialdehyde,spleen index and thymus index were also arrayed.The results indicated that the administration of polysaccharide from purple sweet potato is radioprotective in mice irradiated by 137Cs γ-rays in vivo.

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