磷酸二酯酶-5抑制剂检测方法研究进展

Update of Techniques for Screening of PDE-5 Inhibitors as Illegal Adulterant

DOI：

中文关键词: 磷酸二酯酶-5 抑制剂 检测

英文关键词: PDE-5 inhibitions,determination

基金项目:国家人事部归国留学人员资助计划项目(2006/164)

摘要点击次数: 201

全文下载次数: 984

中文摘要:

3种获准上市的磷酸二酯酶-5抑制剂药物(西地那非、伐地那非和他达那非)在市场上获得了巨大成功。不法商人把这些药品违法添加到植物保健品和药品中谋取利益,对公众的健康构成了威胁。不断出现的PDE-5抑制剂的结构类似物导致问题变得更加复杂。目前,在标准品的参照下,TLC、HPLC、LC-MS和MECC等检测方法可以实现对已知PDE-5药物的检测。只有液相/离子阱串联质谱能够同时检测合法的药物和未知的PDE-5抑制剂类似物。免疫学检测方法正成为快速、灵敏、高效检测PDE-5药物的新方法。

英文摘要:

The success of licensed phosphodiesterase type-5 (PDE-5) inhibitor drugs (viz sildenafil,vardenafil and tadalafil) has led to the widespread use as adulterants in herbal dietary supplements or herbal medicines.Which cause a threat to the public health,in this review,the apply progress of TLC,HPLC,LC-MS and MECC in the analysis of known PDE-5 drugs with the standards were summarized.However,only LC-ESI-MS/MS can be competent for the identification of both the licensed PDE-5 drugs and unknown analogues in herbal products simultaneously.It is believed that Immunoassay may be a promising strategy for rapid detecting of undecared PDE-5 drugs in a simple,sensitive and high-throughput way.

查看全文 查看/发表评论 下载PDF阅读器