羟丙基-β-环糊精/玫瑰香精纳米胶囊制备工艺的优化

Preparation of HP-β-CD & Rose Flavor Nanocapsulates

DOI：

中文关键词: 羟丙基-β-环糊精 纳米胶囊 香精 Box-Behnken响应面法 透射电镜

英文关键词: hydroxypropyl-β-cyclodextrin nanocapsulates flavor box-behnken design the transmission electron microscopy

基金项目:国家973前期基础研究基金项目(2009CB226104);国家自然科学基金项目(20876097);上海市重点新产品项目(08XP0505100)

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中文摘要:

利用羟丙基-β-环糊精(HP-β-CD)内疏水外亲水的空腔结构对东方琥珀玫瑰香精进行包合,以平均粒径为主要指标,粒径分布系数(PDI)及ζ电位为辅助指标对胶囊进行考察。通过单因素实验找出对包合工艺影响较大的因素。在此基础上采用Box-Behnken响应面设计法优化包合工艺,得到最佳包合工艺条件:包合时间为4h,磁力搅拌转速为1 000r/min,反应pH值为8,壁芯质量比为1.69,乳化剂为聚氧乙烯失水山梨醇单月桂酸酯(Tween-20),乳化剂香精质量比为3.13,固形物质量分数为1.5%。其平均粒径为72.8nm,粒径分布系数为0.127,ζ电位为-12.6mV。通过透射电镜观察发现纳米香精胶囊呈不规则的圆形。

英文摘要:

Hydroxypropyl-β-cyclodextrin(HP-β-CD),containing special hydrophobic cavity,was used to include rose flavor.In this study,the average size was as major index and PDI and ζ potentia as t two auxiliary indexes to choose the optimum process parameters.The optimum conditions were determined by single-factor and he Box-Behnken design of response surface methodology and listed as follows: reaction time of 4h,electromagnetic stirring speed of 1000rpm,reaction pH of 8,the mass ratio of external to internal capsule of 1.69,the emulsifier of Tween-20,the mass ratio of emulsifier to flavor of 3.13,solid contents of 1.5%.under the optimum conditions,the average size is 72.8nm,the PDI is 0.127,and the ζ potential is-12.6mv.It also has a spherical shape by the transmission electron microscopy.

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