| 紫心甘薯对四氯化碳、卡介苗加脂多糖诱发小鼠肝损伤的保护作用
| Protective Effect of Purple Sweet Potato on Hepatic Injury Mice
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| DOI：
| 中文关键词: 紫心甘薯 肝损伤 脂质过氧化
| 英文关键词: purple sweet potato liver injury lipid peroxidation
| 基金项目:杭州市科技局科技特派员资助项目(20072532I13)
| 作者
| 单位
| 陈伟平
| 浙江大学城市学院医学与生命科学学院,浙江杭州,310015
| 谢园沁
| 浙江大学医学院公共卫生系营养与食品卫生研究所,浙江杭州,310058
| 胡金鹿
| 浙江大学医学院公共卫生系营养与食品卫生研究所,浙江杭州,310058
| 马晓雯
| 浙江大学城市学院医学与生命科学学院,浙江杭州,310015
| 王珍姝
| 浙江大学城市学院医学与生命科学学院,浙江杭州,310015
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| 中文摘要:
| 研究紫心甘薯对四氯化碳(CCl4)、卡介苗加脂多糖(BCG+LPS)诱发小鼠肝损伤的保护作用。ICR小鼠100只,雄性,按体重随机分为两大组,每大组随机分为5个小组,连续给药12d后,除空白组外,各实验组分别进行如下处理:A组:按10mL/kg剂量腹腔注射体积分数0.1%CCl4油溶液,建立小鼠肝损伤模型;B组:采用尾静脉注射BCG+LPS诱导小鼠免疫性肝损伤。12h后测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)的活性和肝组织中丙二醛(MDA)、还原型谷胱甘肽(GSH)的含量;观察肝脏、脾脏系数的变化。紫心甘薯组各组肝、脾指数、谷丙转氨酶(ALT)、谷草转氨酶(AST)的活性和肝组织中丙二醛(MDA)、还原型谷胱甘肽(GSH)水平与模型对照组各水平相比均具有显著性差异(P
| 英文摘要:
| The objective of this study is to investigate the protective effect of purple sweet potato on liver injury mice which caused by CCl4 and BCG+LPS.For this,a total of 100 male ICR mice were randomized divided into 2 big groups according to the injury methods and then equally randomized into 5 small groups: normal control group,bifendate control group,liver injury control group,low and high dose of purple sweet potato group.Those mice feeding them with corresponded feedstuff.Observed ALT,AST level in the blood and MDA,GSH level in the liver after 12 hours treatment,then calculated the liver and spleen index in the mice.Results: The liver,spleen index,alanine aminotransferase(ALT),aspartate aminotransferase(AST) level in the blood and malondialdehyde(MDA),glutathione(GSH) level in the liver of mice in the treat control groups were significantly different from that in the liver injury control group(P
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