VC对组胺致小鼠的毒性预防及治疗作用

Study of the Prevention and Treatment Action of VC on Histamine Toxicity in Mice

DOI：

中文关键词: 组胺 毒性 维生素C 小鼠

英文关键词: histamine toxicity vitamin C mice

基金项目:教育部国家重点实验室目标导向项目(SKLF-MB-200801)

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中文摘要:

采用常规急性毒理学研究的方法,探讨维生素C(VC)对组胺毒性的预防及治疗作用。组胺对小鼠饮食饮水无影响。组胺引起小鼠的痛阈下降,自主活动减少;肾、胃、肠、胸腺器官指数下降,SOD活力降低,MDA活性升高。VC对痛阈和器官指数下降有较好预防作用,对自主活动和SOD活性改善有明显治疗作用。VC对组胺毒性具有一定的预防及治疗作用。

英文摘要:

To discuss the toxicity induced by histamine on mice and the protective effects of Vitamin C(VC).the results demonstrated that histamine had no effect on drinking water and diet in mice,but it decreased pain threshold and autonomic activity in mice.The index of organ of kidney,stomach,intestinal,thymus and the activities of SOD were reduced by histamine,MDA were increased.VC had a preventive action on pain threshold and the index of organ.VC also had significant effect on SOD activity and autonomous activity.

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