L-赖氨酸合成代谢中NADPH代谢的研究进展

Research Progress on NADPH Metabolism in Constructive Metabolism of L-lysine

DOI：10.3969/j.issn.1673-1689.2012.10.001

中文关键词: L-赖氨酸 代谢途径 NADPH 谷氨酸棒杆菌

英文关键词: L-lysine metabolic pathway NADPH Corynebacterium glutamicum

基金项目:国家863计划项目(2008AA02Z212)

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中文摘要:

L-赖氨酸是人类和动物所必需的但自身不能合成的氨基酸之一,它对平衡氨基酸组成、调节体内代谢平衡、提高体内对谷类蛋白质的吸收、改善动物营养、促进生长发育均有重要作用。L-赖氨酸的发酵不同于L-谷氨酸的发酵,每形成1 mol的L-赖氨酸需要消耗4 mol的NADPH,而每生产1 mol的L-谷氨酸只需消耗1 mol的NADPH,因此在L-赖氨酸发酵过程中,提高代谢途径中的NADPH量是增加L-赖氨酸产量的关键因素之一。作者从谷氨酸棒杆菌中L-赖氨酸生物合成途径、NADPH代谢以及与NADPH代谢相关的酶三个方面概述了L-赖氨酸合成代谢中NADPH代谢的研究进展。

英文摘要:

As one of the essential amino acids for human beings and animals and one of the first restrictive amino acids for human and plants,L-lysine has many functions,such as balancing amino acid composition,adjusting in the body metabolic balance,accelerating the rate of absorption of protein,promoting the growth and development of animals,improving the utilization of protein.It takes around 4 mol NADPH to produce 1 mol L-lysine.However,it takes around 1 mol NADPH to produce 1 mol L-glutamic acid.Therefore,the improvement of NADPH in the pathway of L-lysine fermentation is one of the key factors to increase the output of L-lysine.This paper stated the research evolution focus on aspects of the L-lysine biosynthetic pathways of Corynebacterium glutamicum,the metabolism of NADPH and the NADPH-metabolizing enzymes.

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