不同发酵天数对“栓钱菌质”急性毒性及抗炎、镇痛作用的影响

Effects of Different Fermentation Days on Acute Toxicity and Analgesic,Anti-Inflammatory Activity of Shuanqian Junzhi

DOI：10.3969/j.issn.1673-1689.2013.05.015

中文关键词: “栓钱菌质” 发酵时间 马钱子 急性毒性 镇痛 抗炎

英文关键词: Shuanqian Junzhi fermentation time Strychnos nux-vomica acute toxicity analgesic anti-inflammatory

基金项目:江苏高校优势学科建设工程资助项目(ysxk-2010);南京中医药大学中药学优势学科开放课题(2011ZYX5-001)

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中文摘要:

通过急性毒性试验、小鼠扭体试验和耳廓肿胀试验,比较7个不同发酵天数(0、7、20、41、48、62、69 d)的"栓钱菌质"的急性毒性及抗炎、镇痛作用,研究了不同发酵天数对其毒性效应和抗炎、镇痛作用的影响。实验结果表明,不同发酵天数"栓钱菌质"毒性下降率(%)大小如下:0 d≈7 d48 d>41 d≈20 d>0 d>7 d;与空白对照相比,0、7、20、41、48 d者与马钱子生品一样,均明显减少醋酸致小鼠扭体反应次数(P41 d>48 d>0 d>>62 d>69 d;与空白对照相比,0、7 d、20、41、48 d者与生品相同,皆可显著抑制致炎后小鼠的耳廓肿胀率(P

英文摘要:

To observe the effects of different fermentation days of Shuanqian Junzhi(SQJZ,a Strychnos nux-vomica product fermented by Trametes cinnabarina) on acute toxicity and analgesic,anti-inflammatory activity,seven samples of different fermentation days(0 d,7 d,20 d,41 d,48 d,62 d and 69 d) were applied.The acute toxicity and anti-inflammatory,analgesic activities of SQJZ of different fermentation days were evaluated in animal models.Listed as followed was the acute toxicity of different SQJZ in a descending order:0 d≈7 d48 d>41 d≈20 d>0 d>7 d.According to the control group,the twisting times caused by acetic acid of the crude,0 d,7 d,20 d,41 d,48 d of SQJZ noticeably decreased(P41 d>48 d>0 d>>62 d>69 d.With the control group,0 d,7 d,20 d,41 d and 48 d of SQJZ were able to reduce the swelling of murine external ear caused by croton oil(P

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