酪蛋白酶解物螯合铁对大鼠的补铁效果试验

Experiment on the Effects of HydrolYsed Casein Bound Iron in Iron Supplementation on Rats

DOI：10.3969/j.issn.1673-1689.2013.03.016

中文关键词: 酪蛋白 螯合铁 大鼠 补铁 效应

英文关键词: casein chelated iron rat iron supplementation effective

基金项目:安徽省奶业产业技术体系资助项目

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中文摘要:

以甘氨酸亚铁(Fe2+-Gly)为对照,比较研究酪蛋白酶解物螯合铁(Fe2+-Cas hydr)对缺铁性贫血模型大鼠的治疗效应,探讨酪蛋白酶解物螯合铁作为补铁剂的可行性及效应剂量。首先建立缺铁性贫血大鼠模型,再分Fe2+-Gly及Fe2+-Cas hydr(高、中、低)补饲组和常规日粮、低铁纯和日粮对照组,进行为期36 d的补铁饲喂试验。检测大鼠体重和血液学指标,分析各试验组对贫血症状的治疗效应。结果显示Fe2+-Cas hydr高、中剂量组在36 d试验期后,各项血液指标恢复到正常值范围;相同铁剂量的Fe2+-Cas hydr与Fe2+-Gly贫血恢复效果无显著差异。Fe2+-Cas hydr在铁计量1.818～0.363μg/(g.d)水平之间对缺铁性贫血模型大鼠具有良好的治疗效应。

英文摘要:

The objective of this study is to investigate the feasibility and the effective does scope of hydrolysed casein bound iron(Fe2+-Cas hydr) on cure of iron deficiency anemia(IDA) with Ferrous glycinate(Fe2+-Gly) as the control.The IDA model for rat was first established,and then several groups were divided: the the experimental groups with Fe2+-Gly and Fe2+-Cas hydr in high,medium and low doses respectively,the control group with conventional diet and the Fe-deficient diet group.After 36 days,the weight and the hematology index were measured to analyze the effect of each treatment to anemia.It was found that the hematology index of rats in experimental groups with high and medium doses of Fe2+-Cas hydr recovered to normal range,and no significant differences appeared in the treatment effect of Fe2+-Cas hydr and Fe2+-Gly in the same doses.Fe2+-Cas hydr with iron ranging from 1.818 μg/(g.d) to 0.363 μg/(g.d) is most effective in treating anemia.

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