SDS+HCl催化合成亲水性植物甾醇酯

SDS+HCl Catalyzed Synthesis of Hydrophilic Phytosterol Esters

DOI：10.3969/j.issn.1673-1689.2015.10.003

中文关键词: 植物甾醇 亲水性 聚乙二醇 十二烷基硫酸钠

英文关键词: phytosterols,hydrophilic,polyethylene glycol,sodium lauryl sulfate

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中文摘要:

作者通过两步法将植物甾醇与聚乙二醇结合，即植物甾醇先与琥珀酸酐反应合成植物甾醇琥珀酸单酯（简称单酯），后者再与聚乙二醇酯化制备新型亲水性植物甾醇酯（植物甾醇聚乙二醇琥珀酸二酯，简称二酯）。考察了胶束催化剂对二酯合成的影响，研究了反应条件对转化率的影响。结果表明，十二烷基硫酸钠加盐酸为合成亲水性植物甾醇酯的高效催化剂。在催化剂用量为质量分数6%，单酯与聚乙二醇摩尔比为1∶2，140 ℃下反应2 h目标产物的转化率可达96%。

英文摘要:

The present study was to synthesize novel hydrophilic phytosterol esters through an intermediate phytosterol hemisuccinate, which was first prepared with phytosterols and succinic anhydride and subsequently coupled with polyethylene glycol. The effects of micelle catalyst and reaction conditions were investigated. Results showed that the combination of sodium lauryl sulfate and hydrochloric acid was highly efficient in the catalysis for the ester synthesis. The optimum reaction conditions were: 6% catalyst dose (w/w), 1∶2 molar ratio of phytosterol hemisuccinate to phytosterol polyethylene glycol succinate at 140 ℃ for 2 h. With the optimum conditions, the conversion reached above 96%.

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