淀粉微胶囊对茶多酚的载运及其对餐后血糖反应的影响

Transport of Tea Polyphenols by Starch Microcapsule and Its Effect on Postprandial Blood Glucose Response

DOI：10.3969/j.issn.1673-1689.2019.08.001

中文关键词: 轻度糊化玉米淀粉 茶多酚 海藻酸钠 壳聚糖 定点释放微胶囊 餐后血糖反应

英文关键词: mildly gelatinized corn starch,tea polyphenols,sodium alginate,chitosan,microen- capsulation,blood glucose response

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中文摘要:

为了保护茶多酚及实现其在小肠上半段的定点释放，实验以轻度糊化玉米淀粉吸附茶多酚，再将其包埋入海藻酸钠和氯化钙、壳聚糖组成的外壁里，得到载运茶多酚的淀粉微胶囊。最好的工艺为1.5 g轻度糊化玉米淀粉，20 mL 25 mg/mL的茶多酚，10 mL 0.25％的海藻酸钠，25 mL 0.1％的壳聚糖，25 mL 1.0％的氯化钙，pH3.5制备的微胶囊包埋率可达84.08％，平均包载量达207.6 mg/g。体外模拟胃肠道实验及小鼠实验均验证了微胶囊实现了对茶多酚的保护及释控，小鼠餐后血糖整体趋势相对平缓，峰值减小且延后。

英文摘要:

In order to target deliver the tea polyphenols（TP） to the duodenum of the small intestine，the microencapsulated TP was prepared and its effect on the postprandial glycemic response to corn starch was investigated. The microencapsulated TP was prepared through a co-gelation of alginate and chitosan in the presence of calcium chloride and tea polyphenol-absorbed corn starch that was mildly gelatinized. The experimental results showed an entrapment rate of 84.08% with a loading capacity of 207.6 mg/g when the capsules were prepared in the optimized conditions：1.5 g modified starch，20 mL tea polyphenol solution（25 mg/mL），10 mL sodium alginate（0.25%w/v），25 mL chitosan（0.1%w/v），25 mL calcium chloride（1.0%） at pH 3.5. The in vitro simulated gastrointestinal experiment demonstrated a significant decrease of gastric release of TP（10.09%） and reduced rapidly digestible starch content（RDS=59.2%） compared to mixture of TP and corn starch. A substantial reduction of the postprandial glycemic response to normal corn starch（29.8% at response peak compared to TP-starch mixture） was also observed in the mouse model experiment. Thus，microencapsulated tea plyphenols，compared to TP itself，is effective to reduce the glycemic response，which can be used as a functional material in practical applications.

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