蛋氨酸限制对高脂饮食小鼠骨骼的改善作用

Effects of Methionine Restriction on Bone of Mice Fed with High Fat Diet

DOI：10.3969/j.issn.1673-1689.2019.08.013

中文关键词: 小鼠 蛋氨酸限制 股骨微结构 骨量 氧化还原状态

英文关键词: mice,methionine restriction,femoral micro-structure,bone mass,redox state

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中文摘要:

研究蛋氨酸限制对高脂饮食小鼠的股骨强度、氧化还原状态和微结构等骨骼生长状况的影响。将54只C57BL/6小鼠随机分为3组：正常对照组（4%脂肪+0.86%蛋氨酸，CON）、高脂组（20%脂肪+0.86%蛋氨酸，HF）与高脂蛋氨酸限制组（20%脂肪+0.17%蛋氨酸，MR）。分别饲喂11、22周后，测定小鼠股骨干重、骨长度、骨密度、骨矿物质含量、骨强度与氧化还原状态，观测22周小鼠的股骨微结构。结果显示：22周的MR小鼠体重与对照组接近；与HF组相比，MR组小鼠的股骨干重、骨长度与骨矿物质含量在11周后显著降低（P0.05），且骨矿物质含量显著高于HF组（PPP

英文摘要:

To investigate the effects of methionine restricted diet on the bone strength，redox state and femur microstructure of mice. 54 mice（C57BL/6） were randomly divided into normal control group（4% fat，0.86% methionine，CON），high-fat group（20% fat，0.86% methionine，HF），and high-fat with methionine restriction（MR） group（20% fat，0.17% methionine，MR）. After 11 and 22 weeks，the femur dry weight，femur length，bone mineral density，bone mineral content，bone strength of femur and redox state were determined，and the femoral micro-structures of 22 weeks mice were observed. Results showed that the weight of MR mice at 22 weeks was similar to that of CON group. Compared with HF group，the femur dry weight，femur length and bone mineral content in MR group decreased significantly at 11 weeks（PP> 0.05） at 22 weeks，and the bone mineral content was significantly higher than HF group（PPP

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