| 褪黑素对脂多糖刺激小鼠体内炎症反应
| Effect of Melatonin on Inflammaofory and Anti-Inflammatory Balance of Mice
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| DOI：
| 中文关键词: 褪黑素 LPS IL-1 IL-10 MPO
| 英文关键词: melatonin lipopolysaccharide interleukin 1 interleukin 10 myeloperoxidase(MPO)
| 基金项目:国家自然科学基金项目(30671525)
| 作者
| 单位
| 代国杰
| 江南大学,食品学院,江苏,无锡,214122
| 朱建津
| 江南大学,食品学院,江苏,无锡,214122
| 高琳琳
| 江南大学,食品学院,江苏,无锡,214122
| 单立娟
| 江南大学,食品学院,江苏,无锡,214122
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| 中文摘要:
| 研究脂多糖(LPS)刺激时,褪黑素对小鼠炎症反应的影响。用脂多糖建立炎症反应模型,检测肝脏中白介素-1(IL-1)、白介素-10(IL-10)水平,血清中一氧化氮(NO)、一氧化氮合酶(NOS)以及小肠髓过氧化物酶(MPO)的活性变化。在LPS刺激后4 h时,灌胃褪黑素的小鼠IL-1和小肠MPO明显低于灌胃生理盐水组和正常组,而IL-10高于灌胃生理盐水组和正常组,刺激后16 h时,IL-1、IL-10和MPO均较刺激后4 h有所降低。褪黑素对LPS所诱导的炎症反应有明显的抑制作用,有助于维持机体炎症/抗炎症平衡,保护机体免受炎症损伤。
| 英文摘要:
| In this study,the physiological parameters of melatonin live,including inflammatory cytokine IL-1,IL-10 of spleen,intestinal myeloperoxidase(MPO) were determined after LPS treat.It was found that content of IL-1 and MPO activity decreased but IL-10 increased after 4 h stimulation by LPS.For the case of 16 h,the values of IL-1,IL-10 and MPO activity were lower than that of 4 h.The results indicated melatonin can depress inflammation induced by LPS,maintain inflammatory and anti-inflammatory balance and protect animals from injury.
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