壳聚糖降低脂质过氧化作用的研究

Study on the Reduction of Lipid Peroxidization by Chitosan

DOI：

中文关键词: 壳聚糖 抗氧化 脂质

英文关键词: chitosan anti-oxidation lipid

基金项目:国家自然科学基金项目(20571034,20876068);食品科学与技术国家重点实验室目标导向项目(SKLFMB-200805);江苏省重点成果转化项目(BA2009082);福建省青年科技人才创新项目(2009J05038);漳州师范学院博士启动课题项目(L20812)

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中文摘要:

通过体外油脂抗氧化试验,与常规抗氧化剂VC进行对照;大鼠喂养试验,测定体内脂质过氧化的指标。添加质量分数为0.02%的壳聚糖对猪油和粗榨菜油均有抗氧化作用,但不如等量VC效果明显,但当添加质量分数增大为0.05%后,壳聚糖与VC在实验后期抗氧化能力接近;壳聚糖能显著降低大鼠高脂饮食引起的血清游离脂肪酸浓度上升,降低脂质过氧化物代谢产物丙二醛的含量,提高机体主要的抗氧化酶超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性。因此,壳聚糖能通过调节体内抗氧化酶活性来改善脂质过氧化的状况。

英文摘要:

The in vitro and in vivo effect of chitosan on the reduction of lipid peroxidization was studied in this manuscript.The results showed that chitosan at an addition of 0.02%had antioxidation effect on the lard and crude rape oil,but the activity was worse than that of ascorbic acid.0.05%chitosan and ascorbic acid exhibited the similar activity on the lipid peroxidization. And the chitosan significantly reduced the concentrations of serum free fatty acid and Malondialdehyde and but increased the activities of superoxide dismutase,catalase and glutathione peroxidase.Those results demonstated that chitosan decreased the lipid peroxidization through regulating the anti-oxidation enzyme activities.

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