奥曲肽对高脂饲养小鼠血糖、血脂及抗氧化能力的影响

Effects of OCT on Blood Glucose、Lipid and Anti-Oxidation Function of Mice Fed with High-Fat Diet

DOI：10.3969/j.issn.1673-1689.2012.07.012

中文关键词: 奥曲肽 高脂 血糖 血脂 抗氧化

英文关键词: octreotide high-fat diet blood glucose lipid anti-oxidation

基金项目:国家十二五科技支撑计划项目(2006BAD27B06)

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中文摘要:

研究奥曲肽(OCT)对高脂饲养小鼠血糖、血脂及抗氧化能力的影响。正常组(control)、高脂组(HFD)、高脂+奥曲肽组(OCT)、高脂+质量分数0.1%硫辛酸(LA)组雄性C57BL/6小鼠喂养3周,在第3周期间腹腔注射奥曲肽0.1mL(20μg/kg),3周后进行葡萄糖耐量试验,测定血TC、TG、HDL-C、LDL-C、AI水平,肝脏、肌肉、脂肪、脑组织ROS、CAT、T-AOC、MDA水平。结果表明:注射OCT能够显著降低高脂饲养小鼠葡萄糖耐量试验血糖曲线下面积及TC、TG、LDL-C、AI水平(p

英文摘要:

The objective of this study is to investigate the effects of OCT on blood glucose,lipid and anti-oxidation function of mice fed with high-fat diet.For this,Process and Methods: Three weeks feeding of C57BL/6 mice was divided into normal group(control),high-fat group(HFD),high-fat +octreotide(OCT) group,high-fat +0.1 wt % lipoic acid(LA) group,and feed 3 weeks.Among them,the OCT group were injected 0.1mL of OCT(20?g/ k g) during the third week,oral glucose tolerance test(OGTT) was done at the end of the third week.The levels of blood TC,TG,HDL-C,LDL-C,AI,levels ROS,CAT,T-AOC,MDA of liver,muscle,fat and brain were measured.It was found that OCT significantly reduce the curve size of blood glucose in OGTT experiment.Compared with HFD group(p

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