α-酮酸作为一种有生物活性的双官能团物质,在医药、饲料、食品、化学合成等方面有着重要的应用。目前α-酮酸主要由化学合成法生产,该法反应步骤多、环境污染严重、产物得率较低。相对化学合成法,发酵法和生物转化合成α-酮酸具有成本低、反应条件温和、环境友好等特点,目前引起越来越多研究者的关注。作者比较分析了化学合成法、发酵法、生物转化法制备α-酮酸的研究进展,并在此基础上对该领域今后的研究方向进行了展望。
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α-keto acids,a kind of bifunctional substances combined with biological activities,are widely used in feed,food additives,chemical synthesis,etc. Currently α-keto acids are produced by chemical synthesis,with the disadvantages of mutiple reaction steps,serious environmental pollution,and low product yield. Compared with the chemical synthesis,biotechnological production of α-keto acids is an abstractive approach due to the low cost,mild conversion conditions as well as environment-friendly mode of production,which have attracted increasingly attention of researchers.In this work,we reviewed the progress of chemical synthesis method,fermentation method,and biotransformation to produce α-keto acids. Finally,the development prospects in this field were outlined.
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