发酵对中药减毒增效的研究进展

Research Progress on Fermentation Engineering to Attenuate Toxicity and Synergize Effect of Toxic Chinese materia medica

投稿时间：2012-11-08

DOI：10.3969/J.ISSN.1673-1689.2013.08.001

中文关键词: 发酵 中药炮制 减毒 增效

英文关键词: fermentation Chinese medicine processing toxicity reducing efficacy enhancing

基金项目:江苏省高校自然科学基础研究项目(06 KJB360083);南京中医药大学中药学一级学科开放课题资助项目;江苏高校优势学科建设工程资助项目;2008年江苏省青蓝工程项目

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中文摘要:

在当今中国,应用毒性中药治疗疑难病症已经非常普遍,但是毒性中药的毒性严重限制了其临床应用。这一难题通常可以通过中药炮制这项独特的技术来解决。发酵技术也是重要的传统中药炮制方法之一。发酵炮制与现代生物技术相结合,正影响着中药的各个领域。作者在大量文献调研的基础上,从动物、植物、矿物药三方面分别综述了发酵炮制在中药减毒增效方面的应用和发展。发酵炮制有毒中药不仅可以保护中药成分活性中心免遭破坏,还可以对其中的毒性成分进行结构修饰,产生新成分,从而扩大毒性中药的适应症。发酵炮制为毒性中药减毒增效提供了一个崭新的途径。

英文摘要:

It is very common to apply toxic traditional Chinese medicines to the treatment of incurable diseases today.But the clinical application of toxic medicines is often limited by their toxicity.This problem is usually solved by the special technology called ‘Chinese medicine processing’.Fermentation is one of the traditional methods of ‘Chinese medicine processing’.Combined with modern biological techniques,it is affecting all areas of traditional Chinese medicine in China.Based on the analyses of the literatures,this paper suggests that processing by fermentation can be applied to three kinds of raw materials of toxic Chinese materia medica,i.e.,plants,animals and minerals,to attenuate their toxicity and synergize their effect.It can also be concluded that processing by fermentation could not only protect active centers of the original components from destruction,but also modify structures of the poisonous components,thereby expanding indications of the toxic Chinese medicines.So we think that fermentation processing provides a new approach of toxicity reducing and efficacy enhancing for toxic Chinese materia medica.

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