反式脂肪酸与内皮细胞凋亡研究进展

Researches on Trans Fatty Acids and Endothelial Apoptoic

DOI：10.3969/j.issn.1673-1689.2013.05.001

中文关键词: 反式脂肪酸 人内皮细胞 凋亡 Caspase酶

英文关键词: trans fatty acids endothelial cells apoptosis caspase

基金项目:国家自然科学基金项目(31201343);山东省科技发展计划项目(2012GNC11030);山东省农业重大应用技术创新项目(鲁财农指[2011]39)

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中文摘要:

鉴于我国居民膳食中反式脂肪酸(TFA)含量呈逐年增高的趋势和国内对TFA与人体健康关系的研究甚少的现状,通过内皮细胞凋亡信号转导来研究TFA对内皮细胞的作用机制,研究TFA对血管壁细胞的影响及其与动脉粥样硬化的关系,为心血管疾病的预防提供科学数据和理论依据。

英文摘要:

Endothelial apoptosis which is an early factor causing endothelial injury,plays an significant role in the early stage of cardiovascular.At present,the effects of TFA on atherosclerosis and othe cardiovascular diseases at home and abroard mainly focus on endothelial cell apoptosis.The were little research of the realationship between TFA and human health in spite of the TFA content of chinese food rising year after year.At present in the fields of domestic research is still in its beginning stage.There were little conculted literature review limitting to the relationship of TFA and huamn health.The mechanism of TFA on endothelial cells mainly focus on endothelial apoptosis signal transduction.The study of the effects of TFA on the endothelial cells was of an important theoretical and social value,and provides theoretical basis and reliable scientific data for the prevention and treatment of cardiovascular diseases.

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