运用双向发酵技术建立中药微生物药代模型的设想

Assumptions of Establishing the Microbial Models of Drug Metabolism of Traditional Chinese Herbs by Applying Bi-Directional Solid Fermentation Technology

DOI：10.3969/j.issn.1673-1689.2013.03.001

中文关键词: 双向发酵 中药 药物代谢 微生物模型

英文关键词: bi-directional fermentation traditional Chinese herbs drug metabolism microbial models

基金项目:江苏高校优势学科建设工程资助项目(ysxk-2010);南京中医药大学中药学优势学科开放课题(2011ZYX5-001)

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中文摘要:

简述传统中药药物代谢研究方法的现状与不足,指出利用微生物药代模型进行中药药代研究的技术优势,认为它为中药药物代谢研究提供了新的思路与方法。通过对独特的"双向发酵"技术实用意义及应用前景的深入分析,提出运用其建立中药微生物药代谢模型的设想。

英文摘要:

In this manuscript,the progress and deficiency of drug metabolism of traditional Chinese herbs were introduced.The technical advantages were pointed out that drug metabolism research was performed by using the microbial models which provide a novel ways for Chinese herbs drug metabolism.Based on the analysis of practical meaning and prospect of the special ’bi-directional fermentation’ technology,the assumption of establishing the microbial models of drug metabolism of Chinese herbs was suggested by applying this technology.

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