天参丸大鼠长期毒性试验研究

Study on Chronic Toxicity Test of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng on Rats

DOI：10.3969/j.issn.1673-1689.2014.07.016

中文关键词: 天参丸 长期毒性试验 大鼠

英文关键词: tibetan radix rhodiolae changbaishan wild ginseng, chronic toxity test, rat

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中文摘要:

观察天参丸对大鼠所产生的长期毒性反应及严重程度，确定临床安全用药剂量。按2.0、1.0、0.5 g/kg 3个剂量连续灌胃大鼠6个月，观察检测给药期第3、6个月及停药1个月后大鼠的生长发育、血常规、血液生化学、肝肾功能、重要脏器指数、组织病理学等变化。结果表明：长期大剂量服用天参丸对大鼠肝肾功能、肌酸激酶、血脂及血液学部分指标有一定的影响，提示本品长期用药的安全剂量为0.5 g/kg以下。

英文摘要:

To observe the long-term toxicity and its severity of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng by rat experiment and provide safe dosage for its clinical usage. The rats were randomly divided into four groups: high(2.0 g/kg), middle(1.0 g/kg), low(0.5 g/kg) group and blank group. The drug group was given oral of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng for 180 consecutive days and observe the changes of the rats' common condition、body weight、hematology、blood biochemistry 、liver and kidney function、coefficient of important organs 、histological during medication and the recovery condition within 30 days of stopping medication. Results shows the long-time use of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng may have a certain impact on some indicators of live function、kidney function、creatine kinase、blood lipids and blood. This experiment indicates that the safe dose of its long-term use should not more than 0.5 g/kg daily.

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