微生物发酵法生产L-亮氨酸的研究进展

Progress on Microbial Fermentation Production of L-Leucine

DOI：10.3969/j.issn.1673-1689.2015.02.001

中文关键词: L-亮氨酸 生物合成 转运蛋白 Lrp

英文关键词: L-leucine,biosynthesis,transporter,Lrp

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中文摘要:

微生物发酵法是目前生产L-亮氨酸最主要的方法。选育L-亮氨酸高产菌株,有利于缩短国内亮氨酸生产与国外生产之间的差距,提高我国L-亮氨酸市场与国际的竞争力。作者概述了L-亮氨酸的生产方法、生物合成过程中酶的调节作用以及转运蛋白和亮氨酸响应蛋白对L-亮氨酸的调控作用,同时概述了国内外L-亮氨酸产生菌育种方法的研究进展。

英文摘要:

Microbial fermentation was the mainly method to product L-leucine presently. Improving the strain production of L-leucine by breeding high-yielding strains is helpful for shortening of the gap with foreign production and improving our international competitiveness with foreign. This paper stated the methods of L-leucine production,regulation of biosynthesis enzymes,transporter and leucine responsive protein,and the research evolution of the breeding of L-leucine hyper-producter were summarized at home and abroad.

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