β-半乳糖苷酶的研究现状与进展

Research Status and Progress on β-Galactosidase

DOI：10.3969/j.issn.1673-1689.2018.04.001

中文关键词: β-半乳糖苷酶 糖苷水解酶家族 催化机制 结构研究

英文关键词: β-galactosidase,glycoside hydrolase family,catalytic mechanism,structure research

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中文摘要:

β-半乳糖苷酶是一种重要的食用生物催化剂，具有催化β-1，4糖苷键水解和转糖苷作用，并被广泛应用于乳糖水解及低聚半乳糖合成。作为糖苷水解酶家族的重要成员，β-半乳糖苷酶在理论与应用方面均积累了丰富的研究成果。作者从酶的家族分布、催化机制形成、分子结构分析及特殊酶学性质发掘等方面对β-半乳糖苷酶的研究现状进行综述，以期为β-半乳糖苷酶催化调控的深入探索与应用开发提供参考。

英文摘要:

β-Galactosidase is an important food biocatalyst，which possesses transglycosylation and hydrolysis of β-1，4 glycoside bonds. These catalytic have been widely used in galacto- oligosaccharides production and lactose hydrolysis. As an important member of glycoside hydrolase family，it has accumulated rich results on research of theory and application of β-galactosidase. In this paper，it is reviewed from perspectives of theory and application，including distribution of β-galactosidase in glycoside hydrolase family，theory of catalytic mechanism，progress on structure research，and development of specific functional. This article is intended to provide reference for further research on the catalytic mechanism regulation and the application development of β-galactosidase.

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