复方红景天缓解体力疲劳活性的研究

Study on the Anti-Fatigue Activity of the Compound ofRhodiola

DOI：10.3969/j.issn.1673-1689.2019.08.019

中文关键词: 红景天 复方 抗疲劳 机制

英文关键词: Rhodiola,compound,anti-fatigue,mechanism

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中文摘要:

依据传统中医药理论，在藏药红景天抗疲劳的基础上，从常用缓解疲劳的中药中优选了黄精、枸杞、当归、五味子、肉苁蓉与红景天组成复方，以期从多个侧面提高抗疲劳活性。以昆明种雄性小鼠为研究对象，随机分成安静对照组、运动对照组、配方一组、配方二组、配方三组和红景天单方组，灌胃30 d。研究结果表明，给药组均能不同程度地延长小鼠游泳时间、降低血清尿素氮、血乳酸的含量，增加肝糖元的含量，其中与红景天单方组相比，配方二和配方三组活性较好，而配方一组与红景天单方组比较无显著性差异。进一步考察了各组对运动小鼠的琥珀酸脱氢酶、肌酸激酶、ATP酶等能量代谢相关酶活的影响，综合比较，配方三组抗疲劳活性效果最显著，表明其中各味中药能够很好地协同发挥作用，对开发复方红景天抗疲劳保健品具有一定的指导意义。

英文摘要:

According to the theories of traditional Chinese medicine，we selected theAngelica，Schisandra，Cistanche，Chinese wolfberry，Polygonatumfrom the commonly used traditional Chinese medicine to relieve the fatigue in combined withRhodiola，in order to improve the anti-fatigue activity. Kunming male mice were randomly divided into 6 groups：the quiet control group，the swimming control group，formula group I，formula group II，formula group III，and single Rhodiola group. All mice were subjected to gavage administration for 30 days. Results showed that the drugs could significantly prolong the swimming time of mice，decrease the content of serum BUN，blood LA，increase the content of liver glycogen. Compared with singleRhodiolagroup，formulation II and III displayed better activities，while there was no significant difference between formula group I and singleRhodiolagroup. Each group was further investigated with SDH，CK，ATP enzyme activities in swimming mice. By comprehensive comparison，formula group III proved the best anti-fatigue effect，indicating the Chinese traditional medicines in formula III other thanRhodiolahad a good synergy effect with it，and that may have some directive significance for the development of novel anti-fatigue health products.

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