宁夏枸杞水提物对四氧嘧啶诱导糖尿病小鼠的降糖作用

Studies on the Hypoglycemic Activity ofLycium barbarumL. Water Extracts

DOI：10.3969/j.issn.1673-1689.2019.03.013

中文关键词: 宁夏枸杞 I型糖尿病 降血糖 抗氧化

英文关键词: Lycium BarbarumL.,type I diabetes mellitus,hypoglycemic activity,anti-oxidant

基金项目:

摘要点击次数: 161

全文下载次数: 271

中文摘要:

枸杞子被证明具有延缓衰老、抗疲劳、抗脂肪肝以及提高免疫力的功效。作者采用四氧嘧啶建立糖尿病小鼠模型研究宁夏枸杞子水提物（LBWE）的降血糖活性，实验中采用盐酸二甲双胍溶液（Met）作为阳性对照。结果证实，与糖尿病模型组相比较，连续28 d灌胃LBWE，小鼠血糖水平显著降低，四氧嘧啶引起的小鼠体重减轻以及摄食、饮水异常症状得到显著改善。LBWE可以抑制葡萄糖耐量试验中血糖水平的升高，进一步证实在四氧嘧啶诱导的糖尿病小鼠中，宁夏枸杞子水提物具有显著的抗糖尿病的效果。此外，4周的LBWE口服，能够显著降低血清中MDA水平并提高SOD和GSH-Px活性，证明LBWE有助于防止与氧化压力相关的糖尿病并发症。本研究表明宁夏枸杞子水提物通过防止氧化损伤而起到降血糖作用。

英文摘要:

Lycium barbarumL. plays roles in anti-aging，anti-fatigue，anti-fatty and immunity improvement. We used alloxan-induced diabetic mouse model to investigate hypoglycemic activity of Lycium Barbarum L. water extract（LBWE）. Metformin hydrochloride solution（Met） was served as positive drug. 28-day LBWE treatment significantly reduced mouse blood glucose compared to model group. LBWE strongly improved alloxan-induced weight loss，abnormal symptoms of food and water intake. The hypoglycemic activity of LBWE was further confirmed by the inhibition of serum glucose in glucose tolerance test. Moreover，LBEW-treated mice showed low MDA and high SOD and GSH-Px activity compared to model group，suggested that LBWE prevented oxidative stress associated with diabetes complications. In conclusion，LBWE has a hypoglycemic effect by preventing oxidative damage.

查看全文 查看/发表评论 下载PDF阅读器