杨梅酮对高脂诱导的肥胖小鼠脂肪肝的预防作用

Preventive Effects of Myricetin in Hepatic Steatosis of Obese Mice Induced by a High-Fat Diet

DOI：10.3969/j.issn.1673-1689.2017.10.012

中文关键词: 高脂 脂肪肝 杨梅酮 氧化应激 脂质代谢

英文关键词: high-fat diet,hepatic steatosis,myricetin,oxidative stress,lipid metabolism

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中文摘要:

研究杨梅酮（Myricetin，MTN）对高脂诱导的肥胖小鼠脂肪肝的预防作用。32只C57BL/6J雄性小鼠随机分为4组：对照组（CT，饲喂正常日粮），对照+杨梅酮组（CT+MTN，饲喂含质量分数0.2%杨梅酮的正常日粮），高脂组（HF，饲喂高脂日粮），高脂+杨梅酮组（HF+MTN，饲喂含质量分数0.2%杨梅酮的高脂日粮）。10周后测定小鼠代谢差异（能量消耗、呼吸交换率、自主活动），血脂水平，肝脏氧化还原状态及脂质沉积情况，同时采用qPCR检测小鼠肝脏脂质代谢相关基因的表达。结果表明与对照组相比，长期高脂日粮导致小鼠体质量显著增加，内脏脂肪沉积，能量消耗显著降低（P

英文摘要:

To study the preventive effects of myricetin（MTN） on hepatic steatosis in mice induced by high-fat diets. Thirty-two male C57BL/6J mice were randomly divided into four groups：control group（CT，fed a standard diet），CT+MTN group（fed a standard diet with additional 0.2% myricetin，w/w），a high-fat diet group（HF），HF+MTN group（fed a high-fat diet with additional 0.2% myricetin，w/w）. When the mice were fed their respective diets for 10 weeks，metabolic differences（including energy expenditure，respiratory exchange ratio，and ambulatory activity），plasma lipid profiles，hepatic redox status and lipid depositon were assessed. Furthermore，the expression of genes that involved in lipid metabolism in liver was evaluated by qPCR analysis. The results showed that when compared to control group，HF group had a significantly higher body weight and lower energy expenditure（P

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