玛咖水提物抗小鼠前列腺增生作用

Protective Effects of Lepidium Meyenii（Maca） Aqueous Extract on Benign Prostatic Hyperplasia in Mice

DOI：10.3969/j.issn.1673-1689.2017.04.006

中文关键词: 前列腺增生 苄基芥子油苷 玛咖水提物 丙酸睾酮 抑制作用

英文关键词: Benign prostatic hyperplasia,benzyl glucosinolate,maca aqueous extract,testosterone propionate,inhibition effect

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中文摘要:

探讨了玛咖水提物抗前列腺增生的药效物质及其作用机理。将50只雄性ICR小鼠随机分为空白组、模型组、阳性药组，玛咖组（60 mg/kg，含苄基芥子油苷1.44 mg/kg）及苄基芥子油苷组（1.44 mg/kg）。除空白组外，其他组连续30 d皮下注射丙酸睾酮（5.0 mg/kg），制造小鼠前列腺增生模型，观察各组小鼠前列腺湿重、前列腺指数；血清中睾酮（T）、雌二醇（E2）、T /E2水平和前列腺酸性磷酸酶的影响及镜下病理学改变。结果显示，与模型组相比，玛咖组和苄基芥子油苷组小鼠前列腺湿重及前列腺指数显著降低（P＜0.01），血清T、DHT含量和T/E2比值明显降低（P＜0.05或P＜0.01），光镜下见前列腺增生程度大为减轻，增生的腺上皮乳头减少或消失，玛咖组的结果与苄基芥子油苷组相似。结果表明，玛咖水提物和苄基芥子油能显著抑制小鼠前列腺增生；苄基芥子油苷是玛咖水提取物抗前列腺增生主要的活性物质。

英文摘要:

The main substance in Maca aqueous extract responsible for the inhibition of benign prostatic hyperplasia（BPH） in mice was investigated in this study and the mechanism was discussed. Fifty male ICR mice were randomly divided into five groups：the control group，the BPH model group，the finasteride group，the Maca extract group treated with 60 mg/kg Maca（containing 1.44 mg/kg benzyl glucosinolate） and the benzyl glucosinolate group with a dose of 1.44 mg/kg. BHP was induced in all mice by subcutaneous injection of testosterone propionate（TP，5.0 mg/kg） with the control group excepted. The inhibitory effects on BPH of Maca extract and benzyl glucosinolate were evaluated using the prostate wet weight，the prostatic index（PI），testosterone（T），dihydrotestosterone（DHT），estradiol（E2），the value of T/E2，the prostatic acid phospatase（PAP） in serum and histopathology examination. Comparing with the BPH model group，the Maca extract group and benzyl glucosinolate group significantly decreased the prostate wet weight and PI（P＜0.01），as well as the values of T，DHT and T/E2 in serum（P＜0.05 or P＜0.01）. A great reduction of BPH was observed with the prostate glandular hyperplasia reduced or disappeared. The similar histological effects were achieved for the Maca group and benzyl glucosinolate group. The results confirmed an effective inhibition of BPH in mice by the Maca aqueous extract and benzyl glucosinolate which was suggested as the main bioactive component in Maca extract.

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