双去甲氧基姜黄素与姜黄素纳米乳药代动力学的比较研究

Comparative Pharmacokinetic Study of BCNE and CCNE

DOI：10.3969/j.issn.1673-1689.2017.04.015

中文关键词: 双去甲氧基姜黄素 姜黄素 纳米乳 药代动力学

英文关键词: bisdemethoxycurcumin,curcumin,nanoemulsion,pharmacokinetics

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中文摘要:

制备并考察双去甲氧基姜黄素纳米乳和单体姜黄素纳米乳的药代动力学特征。雄性SD大鼠口服灌胃分别给予双去甲氧基姜黄素纳米乳和单体姜黄素纳米乳后，于大鼠眼底静脉丛取血，采用HPLC法测定血浆中单体双去甲氧基姜黄素和姜黄素的浓度，DAS 2.1.1药动学软件计算药动学参数。得到双去甲氧基姜黄素纳米乳和单体姜黄素纳米乳主要药动学参数Tmax为1.50 h和1.00 h；Cmax为（85.87±2.53）和（85.60±2.30） μg/L；AUC0~72 h为（788.23±52.04）和（1 345.50±64.88） μg/L·h。表明姜黄素纳米乳的口服生物利用度比双去甲氧基姜黄素纳米乳更好。

英文摘要:

Bisdemethoxycurcumin nanoemulsion（BCNE） and curcumin nanoemulsion（CCNE） were prepared and their pharmacokinetics was evaluated. Plasma samples were collected from the retinal venous plexus of SD rats after oral administration of BCNE and CCNE. The concentration of BC in plasma was determined by HPLC. The pharmacokinetic parameters of BCNE and CCNE were calculated with DAS2.1.1 pharmacokinetic program. Tmax of BCNE and CCNE were 1.50 h and 1.00 h，while Cmax were 85.87±2.53 μg/L and 85.60±2.29 μg/L. AUC0~72 h for BCNE and CCNE were 788.23±52.04 μg/L·h and 1345.50±64.88 μg/L·h，respectively. The oral bioavailability of CCNE exhibited better performance than that of BCNE.

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