星点设计-效应面法优化柚皮素包合物自微乳给药系统

Optimization of Self-Microemulsifying Drug Delivery System for Naringenin-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method

DOI：10.3969/j.issn.1673-1689.2017.03.013

中文关键词: 柚皮素包合物 自微乳 星点设计 效应面法

英文关键词: NAR-β-CD inclusion complex,self-microemulsifying central composite design,response surface

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中文摘要:

研究星点设计-效应面法优化柚皮素包合物自微乳化给药系统最佳处方。通过测定柚皮素包合物在各介质中的溶解度，利用伪三元相图初步筛选柚皮素包合物自微乳给药系统组分；以柚皮素在不同自微乳处方中的载药量和粒径为指标，采用星点设计-效应面优化法，确定最佳处方。柚皮素包合物自微乳最佳处方选择油酸乙酯为油相，聚山梨酯80为乳化剂，PEG 400为助乳化剂，油相比例为14.39%，Km值为2.05，最佳处方中载药量为159.435 mg/g，粒径为28.35 nm。

英文摘要:

This study was aim to investigate the formula of self-microemulsifying drug delivery system for naringenin naringenin-β-cyclodextrin（NAR-β-CD） inclusion complex by central composite design-response surface method. The solubility test of NAR-β-CD inclusion complex in different secondary solvents and pseudotemary phase diagam were utilized to select components of NAR-β-CD inclusion complex self-microemulsifying drug delivery system. According to the drug loading and particle size of naringenin in different self-microemulsifying drug prescriptions，the optimal prescription was determined using the central composite design and response surface method. The optimal prescription of NAR-β-CD inclusion complex self-microemulsifying drug delivery system was composed of Ethyloleate（oil），Polysorbate 80（surfactant），and PEG 400（co-surfactant），with oil ratio of 14.39%，and the Km at 2.05. The drug loading of naringenin was 159.435 mg/g，and particle size was 28.35 nm.

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