The study aimed to investigate the in vivo anti-fatigue effect of an extract from Ruditapes philippinarum. Mice were randomly divided into six groups（normal，mode，positive，three dose groups） and after oral administration for 15 days，the forced swimming models of mice were established. The swimming time with weight loading was recorded and contents of lactic acid（LA） and blood urea nitrogen（BUN） and activities of lactate dehydrogenase（LDH），creatine kinase（CK） and superoxide dismutase（SOD） in mice serum were analyzed. Results showed that the swimming time of high and medium doses of groups with weight loading was longer than that of the mode group，three dose groups after exercise had an obviously reduced content of LA（p
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