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白藜芦醇多不饱和脂肪酸酯的合成
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Synthesis of Polyunsaturated Fatty Acid Esters of Resveratrol
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DOI:10.3969/j.issn.1673-1689.2020.01.005
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中文关键词: 白藜芦醇 多不饱和脂肪酸 白藜芦醇酯 亚麻酸 花生四烯酸 DHA
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英文关键词: resveratrol,polyunsaturated fatty acid,resveratrol ester,linolenic acid,arachidonic acid,DHA
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基金项目:
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摘要点击次数: 66
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全文下载次数: 113
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中文摘要:
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为增强白藜芦醇和多不饱和脂肪酸的稳定性和功效,采用化学法合成白藜芦醇和亚麻酸、花生四烯酸以及DHA等3种多不饱和脂肪酸的酯化产物。以草酰氯为酰化试剂,在N,N-二甲基甲酰胺催化下,将脂肪酸制成相应的酰氯,随后与白藜芦醇反应成酯,运用质谱、红外、氢谱、碳谱等测试手段确认4种白藜芦醇酯的结构。结果表明,白藜芦醇与亚麻酸反应主要生成两种单酯化产物:亚麻酸-3-白藜芦醇酯和亚麻酸-4'-白藜芦醇酯;与花生四烯酸和DHA反应主要得到三酯化产物:三花生四烯酸白藜芦醇酯和三DHA白藜芦醇酯。
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英文摘要:
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To enhance the stability and efficacy of resveratrol and polyunsaturated fatty acids(PUFAs),the esterification products of resveratrol with three kinds of PUFAs,linolenic acid,arachidonic acid and DHA,were synthesized by chemical method. With oxaloyl chloride as acylation reagent,the PUFAs were prepared into corresponding acyl chlorides under the catalysis of N,N-dimethylformamide,and then reacted with resveratrol to form esters. The structures of four resulted resveratrol-PUFA esters were identified by MS,IR,1H-NMR and 13C-NMR. The results showed that resveratrol reacted with linolenic acid to form two monoesters: linolenic acid-3-resveratrol ester and linolenic acid-4'-resveratrol ester. Meanwhile,resveratrol reacted with arachidonic acid and DHA to form triesters: triarachidonic acid-resveratrol ester and triDHA-resveratrol ester,respectively.
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